You could try and get really creative with formula queries and a combination of the Size(GetRecords()) queries but I don't recommend it. Without doing it for real, you would essentially be creating a field that finds the first occurrence in your data set where that title appears and making a number value that flags that specific one as 1, and all of the other entries as 0 and then counting that field in your report.
At the end of the day you probably do want to get the # of unique entries somewhere else anyway otherwise reporting might be a little funky. For example if you have a table for lets say employees like so
Title Name
Project Manager A
Project Coordinator B
Project Manager C
And you wanted the count of unique Titles for that table - then you're essentially making a field that is just going to repeat itself
Title Name Unique Titles
Project Manager A 2
Project Coordinator B 2
Project Manager C 2
The idea is that you want to move that value of unique titles somewhere where you can actually report/show that there are only 2 unique values in the data set being evaluated.
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Chayce Duncan
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