Need help on whether to use IF or Case

I'd probably create a Locations table, yeah. And then whatever table has Location in it, look up the related Region from the Locations table onto that table. Much easier to manage.

I created the table with Locations and regions, i am having trouble linking the two tables now. my parent table uses a company # as primary reference , and each company has 1 location. i then try to relate the tables on location to pull the region to the master , but it returns nothing. 

If I'm reading you correctly (never a sure thing), you'll need to create either A) relationships between the Locations table and any tables where you have a Location and want the related Region to show up, or B) a Region field in the intermediate table that looks up to the Location table, which field you'll then look up from there to your parent table.

So I think you have
PARENT table with [Related Company] as a field
COMPANY table with [Location]
LOCATION table

So you either need a relationship between PARENT - LOCATION so that your lookup field in PARENT can 'see' the LOCATION table, or you need to look up [Region] onto the COMPANY table via [Location] and then look up the Region again from COMPANY to PARENT. Which way I guess depends on the nature of your PARENT table. Does that make sense?

yes so i think best way is to just export it into excel and the Vlookup , add the new column to parent table , and call it done. Didn't think outside the box(quickbase)