That is an odd limit as I thought the limit was generally 1,000 API calls per user per day,so maybe your limit is really 20,000 per day (not 2,000) and your post had a typo.
But regardless, all that would happen is that a QuickBase rep may choose to contact you to make ask you to buy more API calls. Since QuickBase is single threaded, I suppose that in theory, a lot of API calls will slow down the app a bit for your users. But whether users perceive a difference in their response time due to this level of APIs would depend on how large and complex your app is in terms of # of records and relationships
