MS Office applications create files. When you do work on a file, it changes, and must be saved. The file you have open persists until you close it, and must be saved (or autosaved) for the work you've done to persist. This is not really analogous to work that's done on Quick Base. Every time you load a different page, whatever you've done before has already been "saved".
AustinK's main question was a little subtle. Do your users have single add or edit record forms open for many minutes at a time? Or perhaps grid edit? Can you tell us more about what you are trying to do?